Publications
1) Digital Transplantation Pathology: Combining Whole Slide Imaging, Multiplex Staining and Automated Image Analysis
K. Isse, A. Lesniak, K. Grama, B. Roysam, M. I. Minervini and A. J. Demetris
2011:American Journal of Transplantation
2) Increasing specimen coverage using digital whole-mount breast pathology: Implementation, clinical feasibility and application in research
Gina M. Clarkea, Chris Peressotti, Paul Constantinou, Danoush Hosseinzadeh, Anne Martel and Martin J. Yaffe
2011:Computerized Medical Imaging and Graphics
3) Biomechanical Property Quantification of Prostate Cancer by Quasi-static MR Elastography at 7 Telsa of Radical Prostatectomy, and Correlation with Whole Mount Histology
D. M. McGrath, W. D. Foltz, N. Samavati, J. Lee, M. A. Jewett, T. H. van der Kwast, C. Ménard and K. K. Brock
2011:The International Society for Magnetic Resonance in Medicine
4) Megapixel Digital PCR
Kevin A. Heyries, Carolina Tropini, Michael VanInsberghe, Callum Doolin, Oleh I. Petriv, Anupam Singhal, Kaston Leung, Curtis B. Hughesman and Carl L. Hansen.
2011: Nature Methods
5) Evaluation of Microscopic Disease in Oral Tongue Cancer Using Whole-Mount Histopathologic Techniques: Implications for the Management of Head-and-Neck Cancers
Sorcha Campbell, Ian Poon Dan Markel, Kevin Higgins, Dan Enepekides, Simon Rapheal, John Wong, Ghassan Allo, Eric Morgen, Nader Khaoum, Ben Smith, Judith Balogh, Robert MacKenzie, Jean Davidson, Dan Wang and Martin Yaffe.
2011: International Journal of Radiation Oncology*Biology*Physics
6) Hypoxia predicts aggressive growth and spontaneous metastasis formation from orthotopically-grown primary xenografts of human pancreatic cancer
Qing Chang, Igor Jurisica, Tevor Do and David W. Hedley.
2011: Cancer Research
7) Evaluating the Extent of Cell Death in 3D High Frequency Ultrasound by Registration with Whole Mount-tumor Histopathology
R.M. Vlad, M.C. Kolios, J.L. Moseley, G.J. Czarnota and K.K. Brock.
2010: Medical Physics
8) Registration of In Vivo Prostate Magnetic Resonance Images to Digital Histopathology Images
A. D. Ward, C. Crukley, C. McKenzie, J. Montreuil, E. Gibson, J. A. Gomez, M. Moussa, G. Bauman and A. Fenster.
2010: Prostate Cancer Imaging, Computer-Aided Diagnosis, Prognosis and Intervention/ Lecture Notes in Computer Science/ Robarts Research Institute/ University of Western Ontario
9) Technical Note: Fiducial Markers for Correlation of Whole-Specimen Histopathology with MR Imaging at 7 Tesla
Deirdre M. McGrath, Roxana M. Vlad, Warren D. Foltz and Kristy K. Brock.
2010: Medical Physics
10) Activation of Src and Src-associated Signaling Pathways in Relation to Hypoxia in Human Cancer Zenograft Models
Nhu-An Pham, Joao M.M.M. Magalhaes, Trevor Do, Joerg Schwock, Neesha Dhani, Ping-Jiang Cao, Richard P. Hill and David W. Hedley.
2008: International Journal of Cancer
11) Developing a Methodology for Three-Dimensional Correlation of PET-CT images and Whole-Mount Histopathology in Non-Small-Cell Lung Cancer
M. Dahele, D. Hwang, C. Peressotti, L. Sun, M. Kusano, S. Okhai, G. Darling, M. Yaffe, C. Caldwell, K. Mah, J. Hornby, L. Ehrlich, S. Raphael, M. Tsao, A. Behzadi, C. Weigensberg and Y.C. Ung.
2008: Current Oncology
12) Effect of Distributional Heterogeneity on the Analysis of Tumor Hypoxia Based Carbonic Anhydrase IX
Vladimir V Iakovlev, Melania Pintilie, Andrew Morrison, Anthony W Fyles, Richard P Hill and David W Hedley.
2007: Laboratory Investigation
13) Imaging and Modulating Antisense Microdistribution in Solid Human Xenograft Tumor Models
Joseph D. Mocanu, Kenneth W. Yip, Julia Skliarenko, Wei Shi, Pierre Busson, Kwok-Wai Lo, Carlo Bastianutto and Fei-Fei Liu.
2007: Clinical Cancer Research
14) Measurements of Aneurysm Morphology Determined by 3-D Micro-Ultrasound Imaging as Potential Quantitative Biomarkers in a Mouse Aneurysm Model
Alyse Goldberg, Pria Pakkiri, Erbin Dai, Alexandra Lucas and Aaron Fenster.
2007: Ultrasound in Medicine & Biology
15) Measurement of Signaling Pathway Activities in Solid Tumor Fine-needle Biopsies by Slide-based Cytometry
Jörg Schwock, James C. Ho. Ed Luther, David W. Hedley and William R.Geddie.
2007: Diagnostic Molecular Pathology
16) Predictive and Pharmacodynamic Biomarker Studies in Tumor and Skin Tissue Samples of Patients With Recurrent or Metastatic Squamous Cell Carcinoma of the Head and Neck Treated With Erlotinib
Mark Agulnik, Gilda da Cunha Santos, David Hedley, Trudey Nicklee, Patricia Pintor dos Reis, James Ho, Gregory R. Pond, Heidi Chen, Shuo Chen, Yu Shyr, Eric Winquist, Denis Soulieres, Eric X. Chen, Jeremy A. Squire, Paula Marrano, Suzanne Kamel-Reid, Janet Dancey, Lillian L. Siu and Ming S. Tsao.
2007: Journal of Clinical Oncology
17) A Phase 2 Clinical and Pharmacodynamic Study of Temsirolimus in Advanced Neuroendocrine Carcinomas
I. Duran, J. Kortmansky, D. Singh, H. Hirte, W. Kocha, G. Goss, L. Le, A. Oza, T. Nicklee, J. Ho, D. Birle, G.R. Pond, D. Arboine, J. Dancey, S. Aviel-Ronen, M-S. Tsao, D. Hedley and L.L. Siu.
2006: British Journal of Cancer
18) A New Wide Field-of-view Confocal Imaging System and its Applications in Drug Discovery and Pathology
Gang Li, Savvas Damaskinos, Arthur E. Dixon and Lucy E. J. Lee.
2005: Optical Methods in Drug Discovery and Development
19) A Phase 2 Trial with Pharmacodynamic Endpoints of the Proteasome Inhibitor Bortezomib in Patients with Metastatic Colorectal Cancer
Helen Mackay, David Hedley, Pierre Major, Carol Townsley, Mary Mackenzie, Mark Vincent, Pam Degendorfer, Ming-Sound Tsao, Trudey Nicklee, Diana Birle, John Wright, Lillian Siu, Malcolm Moore and Amit Oza.
2005: Clinical Cancer Research